Laboratory Tests for the Diagnosis of Clostridium difficile
نویسندگان
چکیده
منابع مشابه
Current knowledge on the laboratory diagnosis of Clostridium difficile infection
Clostridium difficile (C. difficile) is a spore-forming, toxin-producing, gram-positive anaerobic bacterium that is the principal etiologic agent of antibiotic-associated diarrhea. Infection with C. difficile (CDI) is characterized by diarrhea in clinical syndromes that vary from self-limited to mild or severe. Since its initial recognition as the causative agent of pseudomembranous colitis, C....
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Clostridium difficilewas first isolated in 1935 in the normal flora of newborns.1 Since 1978, it has been reported to be a cause of antimicrobial-associated diarrhea, colitis, and pseudomembranous colitis.2 During the late 1970s and early 1980s, several studies concluded that two toxins, toxin A (enterotoxin) and toxin B (cytotoxin), were responsible for the characteristic symptoms of C. diffic...
متن کاملEvaluation of the Xpert Clostridium difficile Assay for the Diagnosis of Clostridium difficile Infection
Infection with Clostridium difficile is a growing concern because of the increasing prevalence and spread of nosocomial infections. Emergence of the hypervirulent 027/NAP1/BI strain is also notable. Existing diagnostic methods have low sensitivity or are time-consuming. Therefore, establishing a rapid and accurate microbiological diagnostic assay is needed. We evaluated the Xpert C. difficile a...
متن کاملDiagnosis of Clostridium difficile infection.
TO THE EDITOR—Despite our long-standing interest in earlier tests for Clostridium difficile toxin [1], we believe that polymerase chain reaction (PCR) technology should simply replace other algorithms for the diagnosis of C. difficile infection, as recently outlined in Clinical Infectious Diseases by Kufelnicka and Kirn [2]. We studied 122 consecutive specimens submitted for C. difficile testin...
متن کاملAccuracy of Xpert Clostridium difficile assay for the diagnosis of Clostridium difficile infection: A meta analysis
BACKGROUND There is an urgent need for rapid and accurate microbiological diagnostic assay for detection of Clostridium difficile infection (CDI). We assessed the diagnostic accuracy of the Xpert Clostridium difficile assay (Xpert CD) for the diagnosis of CDI. METHODS We searched PubMed, EMBASE, and Cochrane Library databases to identify studies according to predetermined criteria. STATA 13.0...
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ژورنال
عنوان ژورنال: Clinics in Colon and Rectal Surgery
سال: 2020
ISSN: 1531-0043,1530-9681
DOI: 10.1055/s-0039-3400476